I have been experimenting with Indigo for a month now, I have about 30 devices deployed. I have not had ANY failed communications so far. (at least that I can notice/log)
I am planning on using Insteon for all the dimmers/switches/receptacles and power modules. I will use Insteon sensors for all doors, windows and water, but I will use mostly Z-wave for motion, light, temperature and humidity.
I have the nest thermostat plugin, Ted 5000 plugin, MyQ plugin and will probably use more (I am hoping someone creates one for Hunter Douglas Powerview blinds).
The tally of devices for doing the whole house is about 125 more insteon devices and 20 Z wave devices.
My question is will a system of this size reliably pass all communications? I have read about people having trouble with dropped packets, etc and resorting to voodoo or meticulous testing and revision of the hardware configurations to get things working reliably.