I just reread your reply and I'm confused: you say your Mojave system but later you say 10.13.6. So, my question is have you experienced the issue with the Mojave beta?
Grr! I keep doing that. It was remote desktop to my Mojave system, and I accidentally clicked on the "About this Mac" for my local machine instead of the remote one.
My Indigo server is running MacOS version 10.14 Beta (18A347e).
When I was running High Sierra, only the 2412U would stop responding after a random amount of time. The W800RF32 and 1-wire adapter would still continue to function. A simple restart fixed it. Once I deleted the AppleUSBFTDI.kext the problem never popped up..
On my Mojave system, it's a different story. All 3 of my USB serial devices completely fail using the Apple driver. If I delete AppleUSBFTDI.kext everything works great (and hasn't randomly disconnected either).